Corona vaccination: vector vaccines cause cerebral vein thrombosis
After corona vaccinations, cerebral vein thrombosis has occurred in rare cases. In some cases, this has led to the death of the vaccinated. Scientists at the University Medical Center in Greifswald now report that only vector vaccines are responsible for this side effect of vaccination.
Early last year, researchers at the University Medical Center Greifswald clarified the causes of cerebral venous thrombosis after vaccination against COVID-19 with the vector vaccine AstraZeneca, developed a laboratory test for detection and a treatment option. The results of the first study with affected women and men from all over Germany are now available. These were published in the New England Journal Medicine.
Very rare but dangerous vaccine side effects
According to a statement (Universitätsmedizin Greifswald; PDF), the results clearly show that the vector vaccines administered AstraZeneca and Johnson & Johnson are solely responsible for the very rare but dangerous side effects of vaccination and not the spike protein or the coronavirus infection. SARS-CoV-2.
Antibodies are triggered by vaccine components
Immune system reactions occur during vaccination against COVID-19 with adenoviral vector vaccines. In very rare cases, complications can occur, such as cerebral venous thrombosis.
According to experts, the cause of severe vaccine-induced immune thrombotic thrombocytopenia (VITT) is antibodies to the thrombocyte protein platelet factor 4 (PF4), which strongly activate blood clotting. These antibodies are triggered by components of the vaccine that bind to PF4.
Affected people from all over Germany
As head of the Institute for Transfusion Medicine at the University Medical Center Greifswald, Prof. Dr. Andreas Greinacher, explains, takes care of the Greifswald doctor and the young scientist Dr. Since March 2021, Linda Schönborn has seen a total of 69 patients from all over Germany who were diagnosed with VITT.
The average age of study participants was 48, the youngest was 18 and the oldest 80. About 60 percent of the group cared for are women. "These patients need support with many questions and uncertainties about what to consider after severe VITT disease," says Greinacher.
"Because VITT is so rare, none of the treating physicians in Europe have as much experience with the disease as the Greifswald working group. In return, VITT patients have actively supported our research. We are very grateful for this. “said the doctor.
Scientific evidence based on sick people
doctor With the help of former VITT patients, Linda Schönborn has now been able to disprove that the immune response against SARS-CoV-2 or the spike protein triggers the dangerous PF4 antibodies in cerebral vein thrombosis.
“Of the 69 VITT patients, eleven women and men experienced a new course of Covid-19 disease. In none of the patients, anti-PF4 antibodies rose after Covid-19. Nobody developed a new thrombocytopenia or a new thrombosis”, explains the doctor.
“If the two immune responses were linked, VITT survivors with Covid-19 disease should show an increase in anti-PF4 antibodies, possibly even reigniting thrombocytopenia and thrombosis. However, this does not occur” , explains the scientist.
"Based on the results of previous laboratory studies, there is now for the first time scientific evidence based on actually sick people that rules out a link between anti-SARS-CoV-2 and the anti-PF4 immune response."
Composition of vaccines based on adenoviral vectors
It is therefore clear that rare thrombotic diseases are only a problem of the composition of vaccines based on adenoviral vectors, ie the vaccines of the companies AstraZeneca and Johnson & Johnson, which could be eliminated by modifying the vaccines.
“Our finding that Covid-19 does not reactivate anti-PF4 antibodies and does not cause thrombosis in VITT patients provides additional insight into the origin, development and treatment of VITT and facilitates decision-making regarding the continuation of vaccination against Covid-19 with an mRNA vaccine,” says Greinacher. (ad)
Author and source informationShow now
This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been verified by health professionals.
Sources:Universitätsmedizin Greifswald: Now it's certain: Vector vaccines alone are responsible for severe prothrombotic side effects (VITT) (PDF), (Accessed: June 28, 2022), Universitätsmedizin Greifswald Linda Schönborn et al: SARS-CoV-2 Infection in Patients with a history of VITT; in: New England Journal Medicine, (published: 06/27/2022), New England Journal Medicine
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot substitute a visit to the doctor.