This is how black cumin oil works in coronary heart disease -

Black seed oil improves endothelial function in coronary artery disease

Coronary heart disease (CHD) causes increasing damage to blood vessels and the heart as the disease progresses, which can become a significant long-term risk. However, black seed oil might alleviate damage to blood vessels.

An Iranian research team from the Tabriz University of Medical Sciences studied the effect of black seed oil (Nigella sativa) on coronary heart disease. The results of the corresponding study were published in the specialist journal "Phytotherapy Research".

Black cumin oil is a versatile remedy

Black cumin oil can be used in various medicinal ways, for example to treat inflammatory skin diseases or to treat indigestion and relieve high blood pressure. Black cumin oil has also been shown to have a positive effect on diabetes.

Efficacy in coronary heart disease studied

The new randomized, double-blind, placebo-controlled clinical study has now examined the effect of black cumin oil on endothelial function and various parameters of atherosclerosis in patients with coronary heart disease.

Sixty people between the ages of 35 and 65 were divided into two groups for the study, with one group taking two grams of black seed oil daily for eight weeks and the other group receiving sunflower oil as a placebo.

Serum levels of so-called adhesion molecules, oxidative markers and various parameters of atherosclerosis (hardening of the arteries) were examined at the start and end of the eight weeks.

Significant improvements observed

Researchers found that levels of vascular cell adhesion protein 1 (sVCAM-1) and intercellular adhesion molecule 1 (sICAM-1) decreased massively after black seed oil supplementation, while total antioxidant capacity was increasing.

Black seed oil shows a potentially positive effect on endothelial function by lowering ICAM-1 and VCAM-1 levels and improving oxidative markers, experts say.

Review therapeutic use

Such a therapeutic agent with antioxidant and anti-inflammatory effects could be a practical approach to endothelial dysfunction associated with atherosclerosis. Further studies are now needed to investigate black seed oil as a therapeutic agent and adjunctive therapy in stable coronary heart disease. (fp)

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This text corresponds to the specifications of the specialized medical literature, medical guidelines and current studies and has been verified by health professionals.


Omid Mohammad Tavakoli-Rouzbehani, Mohsen Abbasnezhad, Sorayya Kheirouri, Mohammad Alizadeh: Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary heart disease: a randomized, double-blind, patient-controlled clinical trial placebo; in: Phytotherapy Research (published 07/24/2022),

Important Note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot substitute a visit to the doctor.